Conception et optimisation de procédés supercritiques appliqués aux dispositifs médicaux de cardiologie et neurologie interventionnelles (thèses 2022 - 2025)
Activités
dispositifs médicaux,
CO2 supercritique,
extraction, imprégnation, stérilisation
Publications scientifiques au M2P2
2026
Zohra Laggoune, Yasmine Masmoudi, Valentine Pepe, Elisabeth Badens. Implantable Polymer-Based Medical Devices Go Supercritical: From Cleaning to Sterilization. Annals of Biomedical Engineering, 2026, ⟨10.1007/s10439-026-04392-3⟩. ⟨hal-05782949⟩ Plus de détails...
The biomedical industry has made significant progress in recent years with the emergence of medical devices made from biocompatible polymers, improving implant performance, longevity, and patient safety. However, a major challenge for manufacturers remains the incompatibility of certain polymers with conventional processing techniques involving organic solvents or harsh operating conditions. Supercritical CO2 offers a sustainable and environmentally friendly alternative that can be applied throughout the manufacturing cycle of medical devices, including cleaning, impregnation, foaming, and sterilization. It enables the recovery of a dry, residue-free final product while preserving the integrity and functionality of the material. This article provides a comprehensive and up-to-date review of the latest developments in the use of supercritical CO2 for the different stages of manufacturing and treatment of implantable medical devices. It evaluates scCO2- based process efficiency across various applications and emphasizes processing aspects such as operating modes, key parameters, and process conditions. The review discusses the potential for scale-up and industrial implementation, providing insights into the practical challenges, advantages, limitations, and prospects of scCO2 technology in processing implantable polymer-based medical devices, with a particular focus on chemical engineering aspects.
Zohra Laggoune, Yasmine Masmoudi, Valentine Pepe, Elisabeth Badens. Implantable Polymer-Based Medical Devices Go Supercritical: From Cleaning to Sterilization. Annals of Biomedical Engineering, 2026, ⟨10.1007/s10439-026-04392-3⟩. ⟨hal-05782949⟩
Zohra Laggoune, Yasmine Masmoudi, Seyed Ali Sajadian, Elisabeth Badens. Sirolimus solubility in supercritical carbon dioxide: Measurement and modeling.. Journal of CO2 Utilization, 2025, 93, pp.103034. ⟨10.1016/j.jcou.2025.103034⟩. ⟨hal-04954883⟩ Plus de détails...
The solubility of drugs in supercritical carbon dioxide is a key parameter in their processing. This study focuses on sirolimus, an immunosuppressive drug used in organ transplantation. Its solubility in supercritical carbon dioxide was measured using a static gravimetric method. Measurements were carried out at pressures ranging from 12.5 MPa to 25.0 MPa and temperatures from 313 K to 328 K. The findings revealed a molar fraction range of sirolimus between 1.20 × 10 6 and 2.73 × 10 6 and a direct solubility behavior in the investigated domain. The experimental data were correlated using several models. These included semi-empirical density-based models (Chrastil, Mendez-Santiago and Teja, Bartle et al., Kumar and Johnston, Sparks et al., and Sodeifian et al.), as well as equation of state-based models (Soave-Redlich-Kwong and Peng-Robinson). The results indicated that Sparks et al. and Soave-Redlich-Kwong showed the lowest average absolute relative deviation (AARD%) and the corrected correlation coefficient (Radj) of 4.12 %, 0.978 and 05.18 %, 0.980 respectively.
Zohra Laggoune, Yasmine Masmoudi, Seyed Ali Sajadian, Elisabeth Badens. Sirolimus solubility in supercritical carbon dioxide: Measurement and modeling.. Journal of CO2 Utilization, 2025, 93, pp.103034. ⟨10.1016/j.jcou.2025.103034⟩. ⟨hal-04954883⟩
