Shellfish profession is jeopardized by water quality problem that concerns inlet, with the need to protect the animals from pathogens contaminations, and effluents potentially harmful for the environment with the presence of pathogens, nutrients or organic matter. In this study, ultrafiltration was tested to answer these issues. The objective of the work was two-fold: (i) treat a real effluent from an oyster breeding, the pilot had to continuously face a water containing organic matter and pathogens and (ii) use ultrafiltered water to feed an oyster spat. The process was proved to be efficient in terms of total suspended solids (TSS) and bacterial retention, and especially for Vibrio bacteria, some of whom are potentially harmful for shells. The sustainability of the process facing this pollution was demonstrated and thus for different filtration conditions. Indeed, backwashes and air-backwashes performed were efficient enough to control the fouling generated, so a chemical cleaning was necessary about every 12 h. Water quality parameters, physico-chemical and bacterial, of ultrafiltered effluents were similar to the one obtained with a classical seawater used to feed oyster spats. Ultrafiltration was efficient to treat an effluent from oyster farm and produce water allowing the grown of juveniles. This process could be a solution to reuse effluents in shellfish farms.