Élaboration de systèmes à libération contrôlée de principes actifs ophtalmiques en milieu supercritique (thèse 2016 - 2019)
Publications scientifiques au M2P2
2020
Kanjana Ongkasin, Yasmine Masmoudi, Thierry Tassaing, Gwenaelle Le-Bourdon, Elisabeth Badens. Supercritical loading of gatifloxacin into hydrophobic foldable intraocular lenses - Process control and optimization by following in situ CO2 sorption and polymer swelling. International Journal of Pharmaceutics, 2020, 581, pp.119247. ⟨10.1016/j.ijpharm.2020.119247⟩. ⟨hal-02513973⟩ Plus de détails...
The supercritical impregnation process was used as a green technology for the elaboration of drug delivery intraocular lenses to mitigate the risk of post-operatory endophthalmitis after cataract surgery. Commercially available hydrophobic acrylic (copolymer of benzyl methacrylate and methyl methacrylate) intraocular lenses (IOLs) were impregnated with gatifloxacin, a fourth generation fluoroquinolone drug, using pure supercritical CO 2 (scCO 2) to obtain solvent-free loaded implants. The interaction phenomena involved in the supercritical impregnation were studied by following in situ scCO 2 sorption within the polymer support and the subsequent IOL swelling, and by taking into account drug solubility in the supercritical fluid phase. The drug impregnation yields determined though in-vitro release studies varied between 0.33 and 1.07 ± 0.07 μg•mg −1 IOL in the studied experimental conditions (8 to 25 MPa, 308 to 328 K and 30 to 240 min impregnation duration). An impregnation duration longer or equal to the time required for a complete CO 2 uptake by the polymer as well as a higher pressure or a higher temperature over the crossover pressure delimiting the upper limit of the retrograde solubility zone, led to higher drug impregnation yields.
Kanjana Ongkasin, Yasmine Masmoudi, Thierry Tassaing, Gwenaelle Le-Bourdon, Elisabeth Badens. Supercritical loading of gatifloxacin into hydrophobic foldable intraocular lenses - Process control and optimization by following in situ CO2 sorption and polymer swelling. International Journal of Pharmaceutics, 2020, 581, pp.119247. ⟨10.1016/j.ijpharm.2020.119247⟩. ⟨hal-02513973⟩
Kanjana Ongkasin, Yasmine Masmoudi, Christian Wertheimer, Anna Hillenmayer, Kirsten Eibl-Lindner, et al.. Supercritical fluid technology for the development of innovative ophthalmic medical devices: Drug loaded intraocular lenses to mitigate posterior capsule opacification. European Journal of Pharmaceutics and Biopharmaceutics, 2020, 149, pp.248-256. ⟨10.1016/j.ejpb.2020.02.011⟩. ⟨hal-02513976⟩ Plus de détails...
Kanjana Ongkasin, Yasmine Masmoudi, Christian Wertheimer, Anna Hillenmayer, Kirsten Eibl-Lindner, et al.. Supercritical fluid technology for the development of innovative ophthalmic medical devices: Drug loaded intraocular lenses to mitigate posterior capsule opacification. European Journal of Pharmaceutics and Biopharmaceutics, 2020, 149, pp.248-256. ⟨10.1016/j.ejpb.2020.02.011⟩. ⟨hal-02513976⟩
Journal: European Journal of Pharmaceutics and Biopharmaceutics
Kanjana Ongkasin, Martial Sauceau, Yasmine Masmoudi, Jacques Fages, Elisabeth Badens. Solubility of cefuroxime axetil in supercritical CO2: measurement and modeling. Journal of Supercritical Fluids, 2019, 152, pp.art.104498. ⟨10.1016/j.supflu.2019.03.010⟩. ⟨hal-02125332⟩ Plus de détails...
In this study, an analytical dynamic method was optimized for small amounts of drugs and used to measure the solubility of cefuroxime axetil in supercritical CO2. After validating the experimental procedure with nimesulide, an active ingredient already studied in the literature, the solubility of cefuroxime axetil in supercritical CO2 was measured at temperatures varying from 308 to 328 K and pressures ranging between 8 and 25 MPa. Experimental values varied between 2.2 × 10-7 and 11.24 × 10-6 (in mole fraction) and a retrograde solubility behavior was observed. The solubility was correlated with semi-empirical density-based models: Kumar and Johnston, Mendez-Santiago and Teja, and Chrastil models. All three models successfully correlated the solubilities of cefuroxime axetil with an average deviation lower than 15 %.
Kanjana Ongkasin, Martial Sauceau, Yasmine Masmoudi, Jacques Fages, Elisabeth Badens. Solubility of cefuroxime axetil in supercritical CO2: measurement and modeling. Journal of Supercritical Fluids, 2019, 152, pp.art.104498. ⟨10.1016/j.supflu.2019.03.010⟩. ⟨hal-02125332⟩
