Caractérisation rhéologique et transport du mucus bronchique par un appareil d’aide à la clairance mucociliaire (thèse: 2015 - 2018)
Activités
Étude de la rhéologie des mucus
Approche expérimentale et numérique
Publications scientifiques au M2P2
2018
Olivier Lafforgue, Isabelle Seyssiecq, Sébastien Poncet, Julien Favier. Rheological properties of synthetic mucus for airway clearance. Journal of Biomedical Materials Research Part A, 2018, 106 (2), pp.386 - 396. ⟨10.1002/jbm.a.36251⟩. ⟨hal-01678912⟩ Plus de détails...
In this work, a complete rheological characterization of bronchial mucus simulants based on the composition proposed by Zahm et al. [1] is presented. Dynamic Small Amplitude Oscillatory Shear (SAOS) experiments, Steady State (SS) flow measurements and three Intervals Thixotropy Tests (3ITT), are carried out to investigate the global rheological complexities of simulants (viscoelasticity, viscoplasticity, shear-thinning and thixotropy) as a function of scleroglucan concentrations (0.5 to 2wt%) and under temperatures of 20 and 37 °C. SAOS measurements show that the limit of the linear viscoelastic range as well as the elasticity both increase with increasing sclerogucan concentrations. Depending on the sollicitation frequency, the 0.5wt% gel response is either liquid-like or solid-like, whereas more concentrated gels show a solid-like response over the whole frequency range. The temperature dependence of gels response is negligible in the 20-37°C range. The Herschel-Bulkley (HB) model is chosen to fit the SS flow curve of simulants. The evolution of HB parameters versus polymer concentration show that both shear-thinning and viscoplasticity increase with increasing concentrations. 3ITTs allow calculation of recovery thixotropic times after shearings at 100s-1 or 1.6s-1. Empiric correlations are proposed to quantify the effect of polymer concentration on rheological parameters of mucus simulants.
Olivier Lafforgue, Isabelle Seyssiecq, Sébastien Poncet, Julien Favier. Rheological properties of synthetic mucus for airway clearance. Journal of Biomedical Materials Research Part A, 2018, 106 (2), pp.386 - 396. ⟨10.1002/jbm.a.36251⟩. ⟨hal-01678912⟩
Journal: Journal of Biomedical Materials Research Part A
Olivier Lafforgue, N. Bouguerra, Sebastien Poncet, Isabelle Seyssiecq, Julien Favier, et al.. Thermo-physical properties of synthetic mucus for the study of airway clearance. Journal of Biomedical Materials Research Part A, 2017, 105 (11), pp.3025-3033 ⟨10.1002/jbm.a.36161⟩. ⟨hal-01596484⟩ Plus de détails...
In this article, dynamic viscosity, surface tension, density, heat capacity and thermal conductivity, of a bronchial mucus simulant proposed by Zahm et al., Eur Respir J 1991; 4: 311–315 were experiementally determined. This simulant is mainly composed of a galactomannan gum and a scleroglucan. It was shown that thermophysical properties of synthetic mucus are dependant of scleroglucan concentrations. More importantly and for some scleroglucan concentrations, the syntetic mucus, exhibits, somehow, comparable thermophysical properties to real bronchial mucus. An insight on the microstructure of this simulant is proposed and the different properties enounced previously have been measured for various scleroglucan concentrations and over a certain range of operating temperatures. This synthetic mucus is found to mimic well the rheological behavior and the surface tension of real mucus for different pathologies. Density and thermal properties have been measured for the first time.
Olivier Lafforgue, N. Bouguerra, Sebastien Poncet, Isabelle Seyssiecq, Julien Favier, et al.. Thermo-physical properties of synthetic mucus for the study of airway clearance. Journal of Biomedical Materials Research Part A, 2017, 105 (11), pp.3025-3033 ⟨10.1002/jbm.a.36161⟩. ⟨hal-01596484⟩
Journal: Journal of Biomedical Materials Research Part A
