This paper presents the recrystallization of sodium bicarbonate (NaHCO 3 ) using the Supercritical AntiSolvent process. The focus is pointed toward crystal habit and its modification induced by varying the solvent nature. The observed habit is uncommon with crystals exhibiting a "zigzag" shape. High Resolution Scanning Electron Microscopy observations refuted that this shape was due to particle attachment: those "zigzag" particles are likely monocrystals grown in a diffusion-limited media. Firstly, a molecular modeling study shed light on organic solvents that can interact strongly with NaHCO 3 crystals. Such solvents were found to be ethylene glycol and glycine, in contrast to ethanol or water which likely interact weakly with NaHCO 3 crystals. An experimental campaign confirmed the predicted interactions. Ethylene glycol interactions with NaHCO 3 crystals led to the production of a different crystal salt. Alternatively, adding glycine as a growth inhibitor led to the initial polymorphic form, although with a modified growth mechanism.